Intermediate
2',4'-Dichloroacetophenone CAS:2234-16-4
2,4-Dichloroacetophenone has the general chemical properties of acetophenone, and the carbonyl group can undergo addition, reduction and other reactions. Since there are two chlorine atoms on the benzene ring, it has certain chemical activity and can undergo nucleophilic substitution reactions. The chlorine atom can be replaced by other groups. For example, under alkaline conditions, the chlorine atom can be replaced by hydroxyl, amino and the like.
| Melting Point | 33-34℃(lit.) |
| Boiling Point | 140-150℃ 15mm Hg(lit.) |
| Density | 1.32 |
| Flash point | >230°F |
| Form | Solid |
| Packaging | 25KG Bag |
2,4-Dichloroacetophenone is the raw material for preparing ω-bromo-2,4-dichloroacetophenone or ω-2,4-trichloroacetophenone. The latter two are intermediates for preparing fungicides such as imazalil, propiconazole, and ethiconazole, as well as intermediates for insecticides such as chlorfenapyr and herbicides such as diazinon.
2,4-Dichloroacetophenone is an important organic synthesis intermediate, which is used to synthesize a variety of drugs, pesticides, spices and other organic compounds. For example, it can be used as an intermediate for synthesizing drugs for the treatment of cardiovascular diseases, as well as some pesticide intermediates with insecticidal and fungicidal activity.
Used as a pharmaceutical intermediate for the synthesis of ketoconazole
In pharmaceutical research and development, its derivatives may have certain biological activities and can be used as lead compounds for structural modification and optimization to develop new drugs.
2,4-Dichloroacetophenone is irritating to the eyes, skin, and respiratory tract. Contact should be avoided during use. If it accidentally comes into contact with the eyes or skin, rinse immediately with plenty of water and seek medical treatment.
It should be stored in a sealed container in a cool, dry, well-ventilated place, away from sources of fire and oxidants.