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2-Chloro-3-cyanopyridine CAS 6602-54-6 - Top China Suppliers & Factory for High-Quality Chemicals
The product is prepared by chlorination reaction of 3-cyanopyridine nitrogen oxide and a chlorinating agent. Phosphorus pentachloride is used as a chlorinating agent and phosphorus oxychloride is used as a solvent to react 3-cyanopyridine nitrogen oxide and phosphorus pentachloride. After the reaction is completed, phosphorus oxychloride is removed by vacuum distillation. Ice water is slowly added to the distillation residue, cooled and crystallized, filtered, washed with cold water, and dried to obtain the target product.
1. Chlorination Reaction
React 3-cyanopyridine nitrogen oxide and phosphorus pentachloride (chlorinating agent) in phosphorus oxychloride (solvent).
2. Vacuum Distillation
After the reaction is completed, the phosphorus oxychloride solvent is successfully removed by vacuum distillation.
3. Isolation & Drying
Add ice water to the residue, cool, crystallize, filter, wash with cold water, and dry to obtain the target product.
Frequently Asked Questions (FAQ)
How is the chlorination reaction initiated for this product?
The reaction is prepared by reacting 3-cyanopyridine nitrogen oxide and phosphorus pentachloride, which serves as the chlorinating agent.
What solvent is utilized during the chlorination process?
Phosphorus oxychloride is used as the solvent to react the 3-cyanopyridine nitrogen oxide and phosphorus pentachloride.
How is the phosphorus oxychloride solvent removed after reaction?
Once the reaction is completed, the phosphorus oxychloride is removed from the mixture by vacuum distillation.
What is the procedure for treating the distillation residue?
Ice water is slowly added to the distillation residue, which is then cooled and crystallized.
How is the final target product collected and purified?
The crystallized product is filtered, washed with cold water, and dried to obtain the final target product.