Intermediate
2-Chloro-5-chloromethylthiazole C4H3Cl2NS CAS:105827-91-6
2-Chloro-5-chloromethylthiazole (abbreviated as CCMT) is a pale yellow crystalline or pale yellow liquid with a content of ≥98% and a melting point of 29-31℃. It is an essential intermediate for the synthesis of second-generation neonicotinoid insecticides such as thiamethoxam, thiamethionam, and chlorothalonil. The mechanism of action of second-generation neonicotinoid insecticides is similar to that of the first-generation ones, but they have the advantages of lower dosage, broader spectrum of action, and higher safety. They can not only control above-ground and underground pests but also treat stems, leaves, soil, and seeds.
The configuration method is as follows: using 3-chloropropene as the raw material, chlorine gas (or compounds that can generate chlorine gas, such as sulfonyl chloride) and the chloroform solution of 1-isothiocyanato-2-propene are simultaneously injected into the refluxing chloroform solution for reaction.
1.Chemical properties: This product is pale yellow a liquid with a melting point of 30℃, a boiling point of 108 - 110℃ at 2.4 kPa. At room temperature, it is needle-shaped crystals and insoluble in water, but soluble in dichloromethane, chloroform, carbon tetrachloride and other solvents.
2.Solubility: Soluble in methanol.
It is used in the synthesis of pesticides thiamethoxam and thiamethionam, as well as in the production of the medicine ritonavir. Currently, thiamethoxam, as a new generation of nicotinic insecticides, has attracted much attention in the pesticide industry and has a promising market prospect; ritonavir, as an inhibitor of human immunodeficiency virus (HIV), is indispensable even without a specific drug.
200L HDPE drums, 200L Iron drums.