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China Suppliers Factory for 2-Chloro-3-Cyanopyridine CAS 6602-54-6 | High-Quality Chemical Products
The product is prepared by chlorination reaction of 3-cyanopyridine nitrogen oxide and a chlorinating agent. Phosphorus pentachloride is used as a chlorinating agent and phosphorus oxychloride is used as a solvent to react 3-cyanopyridine nitrogen oxide and phosphorus pentachloride.
Reaction Stage
Chlorination of 3-cyanopyridine nitrogen oxide using phosphorus pentachloride as the agent and phosphorus oxychloride as the solvent.
Vacuum Distillation
After the reaction is completed, phosphorus oxychloride is efficiently removed through vacuum distillation techniques.
Crystallization & Purification
Residue is treated with ice water, cooled for crystallization, filtered, and washed with cold water before final drying.
After the reaction is completed, phosphorus oxychloride is removed by vacuum distillation. Ice water is slowly added to the distillation residue, cooled and crystallized, filtered, washed with cold water, and dried to obtain the target product.
Frequently Asked Questions
What is the primary chlorinating agent used in this process?
Phosphorus pentachloride is utilized as the specific chlorinating agent for the reaction with 3-cyanopyridine nitrogen oxide.
Which solvent is required for the chlorination reaction?
Phosphorus oxychloride serves as the solvent during the reaction phase of the preparation.
How is the solvent removed after the reaction is complete?
The phosphorus oxychloride solvent is removed from the mixture using vacuum distillation.
What are the cooling and crystallization steps?
Ice water is slowly added to the distillation residue, followed by cooling to trigger crystallization of the target product.
What are the final steps to obtain the target product?
The process concludes with filtration, washing the crystals with cold water, and a thorough drying stage.
Is the addition of ice water immediate?
No, ice water must be added slowly to the distillation residue to ensure proper controlled crystallization.